According to a literature review, what is the estimated cost associated with the failure of research to replicate in the U.S.?

The estimated cost associated with the failure of research to replicate in the U.S. being in the billions of dollars per year highlights the significant economic impact that irreproducible research can have on scientific progress and public trust in research. When studies cannot be replicated, it leads to wasted resources including funding, time, and effort that could have been devoted to more promising areas of inquiry. This financial burden can affect not only the academic research community but also industry applications and policy decisions based on flawed data.

The high costs are often connected to factors such as the need for additional funding to attempt replication efforts, potential lost investments in commercializing unproven findings, and public health implications that arise from relying on non-replicable studies. Thus, recognizing the magnitude of the financial consequences of research failures to replicate is essential for understanding the importance of rigorous scientific practices, thorough peer review, and transparency in research methodologies.